A new polymorphic enzyme, uridine monophosphate kinase: gene frequencies and a linkage analysis. [Full Text: https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(85)92738-2], Ranzani, G., Bertolotti, E., Santachiara-Benerecetti, A. S. Ser. Molec. , cytidine monophosphate (UMP-CMP) kinase 1, cytosolic     Note: Originally Volume II. [Full Text], Segura-Pena, D., Sekulic, N., Ort, S., Konrad, M., Lavie, A. 30: 215-218, 1978. Cell Sci. cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial dCMP can also act as acceptor. Chem. Pharm. antibodies-online.cn, english (english) 56: 562-569, 1999. (1978); Gallango and Suinaga (1978); Ranzani et al. , UMP/CMP kinase Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates. (2002) found that the 228- and 196-amino acid forms of UMP/CMP kinase showed identical enzymatic activity. Cell Genet. These nucleoside diphosphates are required for cellular nucleic acid synthesis (Liou et al., 2002). of the OMIM's operating expenses go to salary support for MD and PhD Uridine monophosphate kinase 3: a genetic marker for susceptibility to Haemophilus influenzae type B disease. Cook, P. J. L., Hamerton, J. L. anti-Cytidine Monophosphate (UMP-CMP) Kinase 1, Cytosolic Antibodies 51 Cytidine Monophosphate (UMP-CMP) Kinase 1, Cytosolic (CMPK1) Antibodies from 15 manufacturers are available on www.antibodies-online.com. Multiple transcript variants encoding different isoforms have been found for this gene. [Full Text], Van Rompay, A. R., Johansson, M., Karlsson, A. Satlin, A., Kucherlapati, R. S., Ruddle, F. H. In this population a polymorphic variant of UMPK, UMPK3, is positively associated with invasive HIB disease (relative risk 3.3). Western blot analysis detected UMP/CMP kinase in all human cell lines examined. 1988. This is the first experimental evidence of a catalytic role involving the characteristic insert of bacterial CMP kinases. Alaskan Eskimos have the highest known prevalence of invasive Hemophilus influenzae type B disease, primarily meningitis: in 1 to 5% of all children in the first 2 years of life. Other designations UMP-CMP kinase 2, mitochondrial, UMP/CMP kinase, cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial, cytidylate kinase 2, mitochondrial UMP-CMP kinase, nucleoside-diphosphate kinase, thymidine monophosphate kinase 2, thymidylate kinase family LPS-inducible member GeneRIFs: Gene References Into Functions , thymidine monophosphate kinase 2 62: 1624-1631, 2002. Giblett et al. 26: 627-635, 1974. [PubMed: 2863446] Fax +49 (0)241 95 163 155, german (deutsch) dGTP and TTP were efficient phosphate donors for UMP and dCMP substrates, but not for CMP. It also gives a structural basis of the mechanism by which either ribose or deoxyribose can be accommodated. donation now and again in the future. Both structures with CMP or dCMP show interactions with the pentose that were not described so far. [PubMed: 172293, related citations] Uridine monophosphate kinase polymorphism in two Venezuelan populations. No difference in levels of naturally acquired HIB anticapsular antibodies between persons with HIB disease and health controls was found. Germany, Phone +49 (0)241 95 163 153 [12], Despite flexibility for different nucleoside analogs, UCK is unique among other nucleic acid kinases in its specificity for ribose analogs over 2’-deoxyribose forms; whereas other proteins in the NMP kinase family will indiscriminately phosphorylate both deoxyribonucleosides and ribonucleosides, UCK2 only accepts ribonucleosides. 56: 562-569, 1999. [Full Text], Cytogenetic location: 1p33 (from NCBI), Cook, P. J. L., Hamerton, J. L. Since cytidine triphosphate is generated by amination of uridine triphosphate, the main source of CMP is from RNA being decomposed by RNAse. Hum. The UMPK1 allele was associated with about 3 times the catalytic activity of the UMPK2 allele, so that UMPK2 homozygotes are relatively deficient of the enzyme. Schloss-Rahe-Str. Am. [15], UCK1 is expressed ubiquitously in healthy tissue, but found in low levels in tumor tissues. [PubMed: 396131, related citations] They observed a classic example of induced fit, where substrate-induced conformational changes in hinge residues result in rigid body movements of functional domains to form the catalytically competent state. accessible. , UMP-CMP kinase 2-like [PubMed: 207182], Giblett, E. R., Anderson, J. E., Chen, S.-H., Teng, Y.-S., Cohen, F. (1975) showed that UMPK and Rh (111700) are linked (lod score of 2.313 at theta 0.05 on the basis of 4 families). These nucleoside diphosphates are required for cellular nucleic acid synthesis. New York: Oxford Univ. Cytidine monophosphate, also known as 5'-cytidylic acid or simply cytidylate, and abbreviated CMP, is a nucleotide that is used as a monomer in RNA. Uridine monophosphate kinase 3: a genetic marker for susceptibility to Haemophilus influenzae type B disease. , cytidylate kinase 2 [Full Text], Gallango, M. L., Suinaga, R. [20] Blocking pyrimidine salvage can prevent DNA and RNA biosynthesis, resulting in reduced cell proliferation. Ser. Conversely, UCK2 has been detected mostly in cancerous cells and healthy placental tissue. , cytidylate kinase The mapping of 8 loci on human chromosome 1 by statistical analysis of gene assortment in somatic cell hybrids. 11(3): 159-161, 1975. (2004) reported the crystal structure of the substrate-free open form of UMP/CMP kinase and compared it to the closed state previously reported for the similar D. discoideum UMP/CMP kinase. [PubMed: 561097, related citations] By searching an EST database for sequences similar to pig UMP/CMP kinase, Van Rompay et al. Biochem. Comparison of all four structures shows that the pentose hydroxyls are involved in ligand-induced movements of enzyme domains. This suggested to Giblett et al. Mutating Ser101 reduces CMP phosphorylation only moderately, but dramatically reduces dCMP phosphorylation. (1975) assigned UMPK to chromosome 1 by study of somatic cell hybrids. [PubMed: 15163660] (1974) found genetic polymorphism of UMPK by means of starch gel electrophoresis.

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